Peter makes a bad joke about a rich family's turkey. Peter mistakenly 'milks' male goats. Peter and Brian have a strange interaction about yelling 'cockadoodle doo' instead of howling at the moon. Peter later cuts off his ears to signal unhappiness.

Peter accidentally sends money to a 'Nigerian prince' scam, leading Carter to demand they go to Africa to get his money back. The family travels to Africa, hoping it will change them, and encounters various humorous situations, and Peter answers a call while held at gunpoint.

Quagmire finds a used condom, leading Peter to make a joke. The family attends a therapy retreat, revealing their incompatibilities. Brian attempts to apologize to a crowd, but they are too focused on political correctness and their own identities. Peter and his friends engage in a 'chick fight' over a law being written on white paper.

The video opens with Stewie promoting a 'Monster energy drink' from a truck. Peter's friends tease him about the Olympics, and Peter receives a letter from his sister, Karen, who the family didn't know about. Karen's arrival for Thanksgiving creates tension due to past childhood terrorizing and embarrassing Peter in front of his friends. Karen eventually carves the turkey and showcases a wrestling move called the 'Toxic Shock'.

Brian attempts stand-up comedy, but his jokes generally fall flat, leading to a discussion about humor and social media. Later, Lois is bothered by Peter not being in bed, leading to a humorous exchange about Peter's gross habits in bed and his discovery of Lois's journal.

Peter and Brian try to come up with horror movie ideas, seeking a scary location for inspiration. Later, Peter seems to have put Brian in an 'obedience school' as Brian is seen guarding the house for 'Michael Myers'. Peter envisions his own funeral, assuming he's dead, and then has a humorous misunderstanding about 'doing the dishes'.

Peter gets into trouble distributing alcohol and marijuana to minors, leading to a courtroom scene. Meg asks Peter for a check for a school trip, and Peter mistakenly uses a Post-it pad instead of checks, then quits his job in a misunderstanding. Peter later defends Quagmire in court related to an underage girl, using a peculiar argument about Quagmire's birthday.

Stewie ignores Lois's calls by using noise-canceling headphones. Quagmire celebrates multiple 'births' on his birthday due to a unusual medical procedure. Brian struggles with low test scores, leading Peter to believe he's stupid and alert the town. A flashback shows Peter and Brian discussing relationship problems and a brain tumor diagnosis for Brian.

Stewie attempts to remove Brian's brain tumor by shrinking down and entering his brain, leading to an amusing interaction with Black Widow. Brian's personality changes post-surgery, becoming more carefree and less intellectual, which Stewie initially regrets but Brian seems to enjoy. Peter and Brian argue about responsibility and life choices.

Peter almost gets a dog (Brian) to breathe underwater in an attempt to save a turkey. The family embarks on a bus trip where Peter has to relieve himself. The family argues about finding a turkey for Thanksgiving, and Peter recounts finding the 'fountain of youth'.

Peter attempts to write a comic strip, which turns out to be offensive. The family hilariously avoids warning others about the 'British coming' during a historical reenactment. Lois's sister, Story, is too busy with a 'blood drive', leading to a discussion about cookies and scented candles.

Stewie gets an intervention from his friends about an addiction. Peter is obsessed with a rope, and Lois tries to stop him from getting ice cream before dinner. Later, Chris's bad eating habits are highlighted, and Peter and Brian offer contrasting advice to someone contemplating suicide.

The family attends a couples' counseling retreat in the Bahamas, where they discover their incompatibilities. Quagmire spots a 'landing strip' which could be their way off the island. The family is told that they were tricked into coming to the retreat. Peter's past trauma and memory are referenced.