Summary
Highlights
There are two main approaches to using these peptides. The "prevention first" approach suggests using MOTS-c first to prevent damage, suitable for younger, healthier individuals. The "repair first" approach recommends using SS-31 first to fix existing mitochondrial damage before optimizing with MOTS-c, which is more appropriate for older individuals with accumulated damage and metabolic issues.
For weeks 1-4, use SS-31 (1-2mg daily) and NAD+ (100mg thrice weekly) to repair damage and provide energy. For weeks 5-12, switch to MOTS-c (10mg split into three weekly injections) and continue NAD+, optimizing the repaired mitochondria. After 12 weeks, take a 4-8 week break and can repeat 2-3 times per year.
Many people use MOTS-c for fat loss and energy but don't see the expected results because they fail to address mitochondrial health. Using MOTS-c alone without proper mitochondrial function is like putting racing fuel in a car with a cracked engine. This video will explain why and present correct protocols.
Mitochondria produce ATP, crucial for energy. NAD+ is vital for this process and declines with age. SS-31 repairs damaged mitochondrial membranes, preventing electron leakage and oxidative stress. MOTS-c activates AMPK, improving insulin sensitivity and reducing reactive oxygen species (ROS) that damage mitochondria, acting as both a performance upgrade and a protective system.
Start with MOTS-c (10mg split into three weekly injections) and NAD+ (100mg thrice weekly) for indefinite prevention and optimization, with occasional breaks. After 4-8 weeks, if significant fatigue or metabolic issues persist, add SS-31 (1-2mg daily for 4-8 weeks) alongside MOTS-c and NAD+. Afterward, return to MOTS-c and NAD+ maintenance.
5-amino-1MQ can be added to both protocols to prevent energy waste and improve NAD+ recycling. Think of SS-31 as the mechanic, MOTS-c as a supercharger, NAD+ as the fuel, and 5-amino-1MQ as fixing an exhaust leak to make the system more efficient.
Both protocols lead to improved energy, recovery, performance, and body composition. However, these peptides enhance, but do not replace, fundamental habits like proper sleep, nutrition, and exercise. If results are not substantial, check dosing or foundational habits.
Cycling is crucial: 12 weeks on, 4-8 weeks off for NAD+ to prevent suppression of natural production. MOTS-c can be used long-term with periodic breaks (4 weeks off every 12-16 weeks). SS-31 is typically used for 4 weeks and then as needed for repair.
These advanced protocols require injection and cycling. They repair mitochondria, restore NAD+ levels, and optimize energy but are not a substitute for training, nutrition, or sleep. For individuals aged 35-55 with declining energy, the repair-first approach is recommended. For younger, healthier individuals seeking prevention, the MOTS-c-first route is best. The presenter shares personal success and invites viewers to join a free community for more information and support.