Trisomy (21, 18, and 13) & Nondisjunction Genetics

Understanding Nondisjunction00:00:00

An overview of meiosis, explaining how homologous chromosome nondisjunction in meiosis I leads to two trisomic cells, while nondisjunction in meiosis II results in one trisomic cell.

Trisomy 21 (Down Syndrome)00:04:45

Detailed associations for Down syndrome using the mnemonic 'ALK AND BEER,' covering cardiac defects, duodenal atresia, early Alzheimer's, and specific physical markers like Brushfield spots and palmar creases.

Trisomy 18 (Edwards Syndrome)00:10:26

Exploration of Edwards syndrome, characterized by the mnemonic 'Edward Scissor Hands,' highlighting key symptoms such as clenched fists, low-set ears, and rocker-bottom feet.

Trisomy 13 (Patau Syndrome)00:12:23

Summary of Patau syndrome using the 'P' mnemonic for puberty/Patau, covering clinical features like holoprosencephaly, cleft lip/palate, polycystic kidney disease, and polydactyly.