The Kidney Project at UCSF

End-stage renal disease affects 1.5 to 2 million people worldwide. Dialysis, while life-sustaining, is a short-term, time-consuming, and expensive solution that doesn't replace all kidney functions. A severe shortage of donors leads to hundreds of thousands of deaths annually for those awaiting kidney transplants.

Scientists at UCSF, in collaboration with national partners, are developing a small, implantable device to replicate the natural functions of a healthy kidney to help patients with renal disease.

The device features super-efficient membranes created with silicon nanotechnology to filter toxins without requiring pumps or electrical power. A bioreactor containing engineered kidney tubule cells will handle other renal activities like maintaining water volume, electrolyte balance, and metabolic functions. This biocompatible device will attach to the circulatory system and remove toxins to the bladder as waste.

This artificial kidney will free patients from dialysis machines, allowing them to lead more normal lives, enjoy greater dietary freedom, and improve their overall quality of life. The project aims to significantly extend and improve the lives of kidney failure patients, while also reducing the high costs and personal burdens associated with the disease.